I vote: Assume all spaces are the same setpoint and temp for a LEED
analysis unless there will be actual, significant differences in the real
building

a) The simulation tool is assuming that the HVAC is trying to do exactly
that
b) Your weather file is an approximation (TMY)
c) You have no idea what the actual thermostats will be set for
d) the simulation will not model the actual control system response
e) LEED has accepted our models with that assumption, which I think is
appropriate based on the above reasons and a variety of others. There's
only so much you can expect from a model of a yet-to-be-constructed
facility!

James V. Dirkes II, P.E., LEED AP